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Liu Y, Chen JY, Shang HT, et al

11 DAF-2/DAF-16 (FOXO) signaling in the gut contributes greatly to longevity regulation, with minor effects on the hypodermis, muscle, and reproductive system

Final phase: Weeks 16-52 The duration of isotretinoin therapy is highly individualised, often depending on factors like dose tolerance , patient weight , and the degree of acne clearance