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Similar content being viewed by others Introduction Autophagy is a highly conserved, catabolic process that secures cellular homeostasis by recycling critical metabolites during starvation

These compounds activate the Nrf2 pathway, a cellular signaling system that upregulates expression of genes involved in antioxidant production including glutathione synthesis enzymes

More globally, the development of phMRI and other molecular imaging biomarkers can reveal therapeutic mechanisms, which will allow drug development and treatment to be tailored toward specific neural circuits and patient populations