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Vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and basic fibroblast growth factor (bFGF) are highly expressed in various tumors and are considered important signal transducers in angiogenesis, involving the MAPK (Mitogen-Activated Protein Kinase), PI3K (Phosphoinositide 3-kinase)/Akt, and other signaling pathways (Sui et al., 2014)