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doi: 10.1042/CS20240346 129 MahmoodRDMorganRDEdmondsonRJClampARJaysonGC

More importantly, the genetic heterogeneity of ALS and the limited numbers of identified genes in sALS patients make the personalized gene therapy more challenging and it is impossible to design clinical trials targeting each specific gene

Severe fatigue is defined according to the Numeric Rating Scale recommended by the European Society for Medical Oncology, with a cutoff score of 4 on a 0-10 scale (37)