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Levels of MMP, TIMP-1, and PAI-1 To further examine the effect of thiols on Col I degradation, MMP-1 in cell culture medium were determined (Figure 4A)

10.3390/ijms231911515 131 PiersmaB.BankR

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Future research should emphasize refined patient categorization, improved dosing and multi-target combination therapies to overcome translational medicine hurdles

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Metformin (Glumetza, Fortamet, others)