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Biochemically, GGT is associated directly with GSH regulation and maintenance of its normal redox status in cells by breaking down extracellular GSH which cannot cross the cellular membrane to release cysteine and glycine building blocks which can more easily cross into the cell for de-novo synthesis of GSH during periods of oxidative stress [26]

Agitation-associated behavioral symptoms in mild cognitive impairment and Alzheimers dementia

10.1038/s43247-025-02169-5 193 HsiaoC

Iron imunomodulates the termination of the inflammatory response, as elevated Fe level increase the M2 phenotype and reduce the pro-inflammatory M1 response, reducing the IL-12/IL-10 balance

Aldrich SM, Regal RE

In summary, the problem in aging and most chronic disease is that our cells lose the ability to make enough Glyteine which results in insufficient glutathione production