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Curcumin, while poorly absorbed in its native form, undergoes significant metabolic transformation in the liver, resulting in metabolites that are excreted in the urine and contribute to its anti-inflammatory effects

Moreover, ILDR enhances the efficacy of ICI through microbiota- and BA-mediated mechanisms, including increased DC activation and CD8+ T cell recruitment, potentially driven by DCA enrichment ( Together, these findings suggest that targeting the microbiotaBA axis may improve the efficacy and tolerability of chemoradiotherapy

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doi: 10.20452/pamw.1427 148 BrochardSet al