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One of the hallmarks of CIPN is axonal degeneration, which is reproduced in in vitro cellular models in the form of shortened neurite length or reduced neurite branches

These immunosuppressive effects constitute a significant bottleneck for RT-induced immunotherapy

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Unlike compounds such as vitamin E or beta-carotene, AST readily crosses the bloodbrain barrier and acts across both hydrophilic and lipophilic environments, enabling broad neuroprotective effects

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