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4a,b and Supplementary Fig

[DOI] [PubMed] [Google Scholar] 135.Chauhan A, Gu F, Essa MM, et al

In contrast, the inhibition of SIRT1 significantly diminished the protective effects of melatonin, suggesting that melatonin plays a crucial role in maintaining mitochondrial function to suppress oxidative stress by modulating the level of SIRT1 in OA progression (137)

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Therefore, various antioxidants, including sulforaphane (229), resveratrol (230233), N-acetylcysteine (NAC) (234, 235), hesperidin (236), flavonoid (237, 238), leptin (239), minocycline, and doxycycline (240), selenium supplements (241), docosahexaenoic acid (DHA) (242), curcumin (243), agmatine (244), and sulindac (245), etc., have been reported to be employed in ASD treatment animal model experiments

In the CNS, MeHg exposure for 3 weeks in a rodent model promoted angiotensin-induced vasoconstriction in isolated basilar arterial