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In this regard, it can be noted that transcription of the gdhA gene initiates from two promoters, one weak, constitutively expressed, called gdhA P1, and another, more potent, called gdhA P2, transactivated by GdhR, a transcriptional regulator whose DNA binding is inhibited by -ketoglutarate (Pagliarulo et al., 2004)

Human transcriptomic analysis were defined using a publicly available NASH gene expression profiling dataset (GSE48452 and 126848) allowing the comparison of biopsy-confirmed NAFL and NASH patients with normal controls

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