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Aberrant activation of Wnt/-catenin and microRNAs also involve autoregulatory feedback loop in cancers, for example, miR218 expression is induced by Wnt signaling and in turn, it augments the Wnt signaling pathway by targeting Wnt signaling inhibitors (SOST, DKK2, and sFRP2) (Hassan et al., 2012)

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To our knowledge, this is the first description in PsA disease of these metabolites correlating with the high inflammatory burden: in that milieu, circulating free amino acids may reflect disease-associated protein catabolism

Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation

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