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Moreover, healthy RPE cells have an enriched mitochondrial population and predominantly rely on mitochondrial metabolism (-oxidation, oxidative phosphorylation, and TCA cycle) to produce adenosine triphosphate (ATP) 10

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Nat Immunol (2021) 22:112739

L-Arginine is an amino acid that serves as a precursor for the synthesis of nitric oxide, a potent vasodilator that plays a crucial role in maintaining vascular health

We show that metabolic rewiring of these pathways by vitamin B12 reduces cholinergic transmission by limiting the availability of free choline required by neurons to synthesize acetylcholine

Leuk Res 33(5):638644 Kusaka M et al (1991) Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent