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Fan HJ, Tan ZB, Wu YT, Feng XR, Bi YM, Xie LP, et al

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On this basis, the designed Gi-F-CAA with assembly enhanced binding (AEB) effect demonstrated substantial inhibition of GPX4 activity by the formation of self-assembled Gi-F nanoparticles, which augmented the oxidative stress of Fenton reaction induced by FeTCPP, leading to remarkably enhanced tumor ferroptosis