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The dose required to achieve targeted weight loss or glycemic control is a therapeutic dose, which may range between 1.7 mg and 2.5 mg

Therefore, the observation that nitrotyrosine adducts are almost exclusively found inside mitochondria 18 suggests that superoxide is generated within the mitochondria and is not derived from other cellular sources

The neurotoxic effects of activated microglia have been demonstrated in vivo

AOPPs are primarily generated through the action of chlorinated oxidants, particularly via the enzyme myeloperoxidase, and play a role in the pathogenesis of chronic inflammatory diseases [142]