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Other studies confirmed that continuous afferent vagal stimulation reduces inflammatory neuroglia in the SN, upregulates rate-limiting enzyme density in the LC, and alleviates motor deficits in PD rat models (111)

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doi: [Research Gate] Kamat, P

10.1016/J.MATURITAS.2013.11.002 34

These metabolites spanned across five key classes: Carbohydrate Metabolomics, Nucleotide and Its Metabolites, Organic Acids and Derivatives, Phosphate Sugars, and Phosphoric Acids, suggesting a metabolic realignment in response to the redox disequilibrium induced by the absence of GR