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Sleep disturbance, stress, inflammatory states, nutritional deficiencies, and reduced activity may not be the primary cause, but they can help maintain pain once PHN has become chronic

Mitochondrial dysfunction could not be compensated by increasing oxidative phosphorylation, so that it was only compensated by activating the glycolytic pathway, which was inefficient at producing ATP (18)

Based on the total induction of antioxidant enzymatic activity, the type of toxicological interaction in fish exposed to the mixture containing the lowest concentration of the two substances was addition in gills, and addition or synergism in the liver

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Int J Mol Sci 22(1):107

As shown previously, organoids derived from Apc mutant tumours showed some sensitivity to serine and glycine depletion, which was not evident in Apc/Kras mutant organoids