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Since MHCII antigen processing occurs throughout the phagolysosomal system, we speculate that the disruption of lysosomes by IAPP aggregates may directly interfere with MHCII antigen processing

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Histological analysis confirmed marked peribronchial and parenchymal immune infiltration following AA exposure, along with significant epithelial thickening - both of which were markedly reduced by melatonin treatment ( Figures 1D-F )

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