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Increased or decreased sensitivity with respect to therapeutic treatment is measured according to methods known in the art for the particular treatment and described below, including, but not limited to, cell proliferation assays (Tanigawa et al (1982) Cancer Res.42: 2159-2164) and cell death assays (Weissenthal et al (1984) Cancer Res.94: 161-173

PARK7/DJ-1 MMP2 GRM2 GRIK2 ENPEP SLC1A3 PTPN1 GRIK5 SLC1A1 GRM4 CACNA2D1 GRM6 GRM1 SLC7A11 GLO1 GRM8 FDPS GRIA2 NOS2 GRM3 GRIK3 SLC1A2 GRIK1 GRM5 PYGM GRIA1 ADORA3 GRM7 GRIA4

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Oncogene, 38 (34), 62116225

Total RNA was extracted with the RNeasy Plus Mini Kit (Qiagen #74134, Germantown, MD)

The mechanism of action indicates that SGLT2 is predominantly expressed in the kidney, with less expression in hepatic tissue ( In conclusion, our study demonstrates the preventive effectiveness of remogliflozin in early-stage liver fibrosis