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Specifically, in ischemic/high-ROS environments, BACH1 tends to be degraded and acts to suppress angiogenesis by inhibiting the Wnt/-catenin signaling pathway and recruiting HDAC1, among other mechanisms

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Supplementary Information 12958_2025_1396_MOESM1_ESM.txt (download TXT Supplementary Material 1

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These models better mimic human BBB structure and neural microenvironment than traditional cell monolayers, providing valuable insight into nanoparticle behaviour before animal or clinical testing