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Enhancing endogenous NO production should provide physiological and more sustained effects

The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving blood flow, and modulation of dopamine and serotonin systems

10.1016/j.giant.2020.100022 91 WangD.-K.ZhengH.-L.ZhouW.-S.DuanZ.-W.JiangS.-D.LiB.et al (2022)

CSE is also regulated during inflammation, for example, during LPS stimulation of macrophages, which leads to increased association of SP1 with the CSE promoter

The conversion of thiols into disulfides can occur via direct substitution or a series of redox reactions