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Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study

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[DOI] [Google Scholar] Nunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H

Mechanistically, lactate accumulation, driven by PKM2, enhances Twist1-K150la, which in turn facilitates Twist1 phosphorylation, nuclear translocation, and regulation of TGFB1 transcription, thereby inducing an EndoMT-associated fibrotic phenotype in ischemic flaps