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A serotype that had disappeared from an RF Borrelia population under the force of immunity could reappear again if even a single of the surviving population was transmitted to a nave animal (Barbour, 1987)

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Primary resistance (e.g., low response rates in TET2/IDH wild-type patients treated with DNMTi) and acquired resistance (e.g., secondary mutations after IDH inhibitor therapy) require deeper molecular characterization ( Likewise, the transcriptional rebound observed following BET inhibition in AML has been mechanistically linked to a compensatory feedback loop mediated by the histone acetyltransferase p300

These efforts will help improve outcomes for patients suffering from this debilitating disease

Vitamin B12 (cobalamin) is a water-soluble vitamin essential for red blood cell formation, DNA synthesis, and neurological function

Mitochondrial efficiency.*