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The pentameric LAMTOR complex was the first identified GEF for RagA/B and their interaction was shown to be dependent on AA and the v-ATPase (Zoncu et al., 2011

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Conclusion: Here we report a novel function of portal fibroblasts as drivers of cholestatic fibrosis, ductular reaction, inflammation, hepatocyte senescence, and HCC in aged mice, demonstrating the key role of the tumor microenvironment

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