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Figure 7A )

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

The roadmap emerged from a virtual workshop held on March 19, 2020

doi: 10.1016/j.plaphy.2017.09.003 28 GullnerG.ZechmannB.KnstlerA.KirlyL

Taken together, these findings suggest that APR-246 could induce tumor cell death through both reactivation of mutant p53 and inhibition of cellular thiol-dependent redox system proteins (GPX4, TXNDR1, GRX1), providing novel combinatorial strategies for AML therapy