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While not strictly required for diagnosis, episodes frequently occur in response to a significant psychological stressor, as seen in this patient whose symptoms began shortly after learning about a school shooting

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Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-B/NLRP3 inflammasome axis

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2024;63(12):e202319583

RA also lowered levels of inflammatory cytokines (IL-6, IL-1, IL-22) and protein expression of COX-2 and iNOS, inhibiting NF-kappa B and STAT3 activation and subsequently reducing pro-survival gene activity dependent on these transcription factors [396]