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Of interest, mature OL clusters expressing genes suggestive of immune function have been identified, for example supporting an MHC-class II-mediated response 71

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In an OGD/R-treated astrocyte-neuron indirect co-culture system, astrocytes in an ischemic state activate the STAT3 signaling pathway, which leads to an upregulation of the lactate-directed glycolytic process and is accompanied by impairment of mitochondrial function