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Similar patterns were also observed in a parallel approach where we projected the tumor profiles onto the cell line-defined PCA space, which emphasizes melanoma-specific genes and reduces the influence of non-melanoma cell genes within the tumor (Figure S2C and Figure 1C)

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however, the GSH-Au NC synergy uniquely elevated GSH/GSSG by 29.1%, a response not reported in separate applications, highlighting novelty while aligning with GSHs role in tomato [23]