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Sodium pump inhibition, enhanced calcium influx via sodium-calcium exchange, and positive inotropic response in cultured heart cells

PARP1 can influence autophagy by upregulating the AMPK pathway and downregulating the mTOR pathway (67)

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It was previously reported that targeted FUS-induced BBB opening facilitates CNS penetration of systemically administered anti-A antibodies to targeted brain regions in the TgCRND8 and APP23 mouse model of AD, therefore reducing plaque load 5 , therefore confirms the feasibility of this strategy in promoting behavioral and memory recovery in a transgenic animal model 6,7

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Overall, the GD:2 binding interface is similar in the predicted structures of the AAGAB-WT::2 trimer and the AAGAB-GD:2 dimer, with a root mean square deviation (RMSD) score of 0.921 (fig