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This common belief usually stems from an incorrect inference that B12 supplements have an appetite-stimulating effect

Currently, excessive NNMT upregulation is implicated in several scenarios, including obesity, metabolic diseases, muscle cell degeneration, and even some types of cancer [2, 4]

The same case study reported palpitations, anxiety, and akathisia (a state of agitation and restlessness) as symptoms following the overdose

This specific gene provides the instructions for making an enzyme that is critical for processing amino acids and converting inactive forms of folate and Vitamin B12 into their active, methylated forms