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References SURMOUNT-5 head-to-head trial (NEJM, May 2025) summary via American College of Cardiology: SURPASS-2 primary publication (NEJM, 2021): Eli Lilly SURMOUNT-1 results announcement (NEJM data): Insights into the Mechanism of Action of Tirzepatide (PMC narrative review): Tirzepatide is an imbalanced and biased dual GIP/GLP-1 receptor agonist (PMC): SURMOUNT-5 GI tolerability / discontinuation data (Applied Clinical Trials, tctmd, DiabetesontheNet coverage): SURMOUNT-1 to -4 GI tolerability (Rubino 2025, Diabetes Obesity & Metabolism): Community sentiment context Reddit GLP-1 side-effect analysis and comparative meta-analyses (PMC): Research Use Only Notice: The content on this page is provided for informational and educational purposes only

The fold change in protein abundance in KO vs

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