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doi: 10.1007/BF00312627 50 LopesP

1136-A LIVER TRANSPLANTATION MANAGES ELEXACAFTOR/TEZACAFTOR/IVACAFTOR LIVER INJURY, AND IMPROVES PULMONARY FUNCTION, WITHOUT RECURRENCE OF LIVER INJURY DESPITE RESUMPTION OF THERAPY FOLLOWING TRANSPLANTATION Richard Gilroy 1 , Sophie Hansen 1,2 , Holly Rupone 2 and Laurie LeClair 2 , (1)Intermountain Health, (2)University of Utah Background: Cystic fibrosis (CF) is a potentially lethal inherited disease caused by mutations of the CF transmembrane conductance regulator (CFTR) gene

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Finally, idiopathic pulmonary fibrosis (IPF) is a particularly aggressive and progressive ILD pathogenically based on an aberrant fibroproliferative wound healing response following multiple alveolar lesions, with a 5-yr survival of 30% 6,7

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422 In SLE, the overexpression of CD38 impairs the PINK-Parkin pathway and disrupts mitophagy, leading to mitochondrial structural defects in SLE patients