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In STZ-diabetic rats, treadmill exercise reduced retinal apoptosis (TUNEL+cells, Bax/Bcl-2 ratio, caspase-3 activation) and restored p-Akt levels in the retina, indicating activation of survival signaling in the diabetic neurovascular unit (242)

However, recent studies have shown them to be important in modulating the innate immune response [105, 106, 107]

Unlike the live SP, which displayed remarkable antioxidant effects and osteoclastogenesis-inhibitory properties, both SP powder and boiled SP lost these biological functions (Supplementary Figs