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Insulin activates the PI3K/Akt signaling pathway, which regulates autophagy, inflammation, and oxidative stress in ovarian granulosa cells, thereby promoting follicular development and improving ovarian dysfunction 331,332,333,334,335

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Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits

PMID: 31123166 Biosci Rep2019 May 14;39(5):BSR20182378

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Crombie' group from American and Hong' group from Korea re-designed the benzenesulfonamido aminopyrimidine scaffold through the introduction of other substituent groups at R 1 , respectively, and got two representative inhibitors 66 and 67 that possessed a low nanomole level of inhibitory potentials [178, 179]