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The discovery of apoE Christchurch and the beneficial effect of the hybrid apoE2 + Christchurch variant in AD mouse models represent major breakthroughs in the field and could accelerate the development of clinical trials to assess the efficacy of AAV-mediated apoE therapy in AD [236]

As previously discussed, aerosolized A1AT has a positive impact on neutrophil-mediated killing of P

This data suggests that the variants induce a different downstream transcriptional programme in response to metabolic stress, in line with our observation of a significantly reduced expression of the cytokine Ccl2 in starved C3H10T1/2 adipocytes when we overexpressed the R72 compared to the P72 variant

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10.1002/j.1460-2075.1994.tb06418.x 62