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The 1976 NTTA minutes also describe "[o]ne smuggler [who] is known to have run three or four trailer-loads of cigarettes into Michigan every week, even when the tax there was only 5 or 6 cents

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While the MTT data cannot be translated directly to in vivo human effects, they do raise concern about the potential for these chemicals to cause harm to users at the concentrations currently used in some refill fluids

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Nicotine Replacement Therapy (NRT) Nicotine replacement therapy (NRT) is a widely used treatment strategy to help individuals quit smoking

This article goes into more detail about how these alarms work