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Scientific Overview Dihexa binds to hepatocyte growth factor (HGF) with high affinity and potentiates its activity at the c-Met receptor in research settings

doi:10.1002/1098-108x(200011)28:3 3.0.co;2-3 53

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58,59 Cellular senescence represents a response to stress-induced proliferative arrest

Any use outside of a supervised clinical trial setting would be inappropriate and potentially unsafe

In some embodiments, the formulations or compositions described herein have a pH and osmolarity as described herein, and have a concentration of active pharmaceutical ingredient between about 1 M and about 10 M, between about 1 mM and about 100 mM, between about 0.1 mM and about 100 mM, between about 0.1 mM and about 100 nM