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There is a fundamental distinction between NADPH++H and NADH++H in biochemistry: NADH is oxidized by the respiratory chain to generate ATP, whereas NADPH serves as a reductant in biosynthetic processes

Non-oral routes, such as intravenous injection, can bypass some of these issues

Jin, K., Li, T., Chow, H

Amide-linked PROTACs were obtained by reducing the azide group of the resin 130 to the amine group via the Staudinger reaction, subsequently forming the amide linkage with the target ligand

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