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In refractory cases, more invasive options may also be considered

CRID2 2-hydroxyanthracen-9(10H)-one - a xanthone Mammea from africana, 38% total inhibition at 0.033 mM 2-[(1-methyl-1H-pyrrol-2-ylsulfonyl)methyl]aniline - 28.0% inhibition at 0.1 mM 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8-methyl-1,5,7-tris(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione - a benzophenone Garcinia smeathmannii, 41% total inhibition at 0.033 mM 3-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)propane-1-sulfonyl fluoride - - 3-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)propionic acid - - 3-chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)-propenamide - - 3-ethyl-2-oxo-3,3a,7a,9b-tetrahydro-2H,4aH-1,4,5-trioxadicyclopenta[a,hi]indene-7-carboxylic acid - an iridoid from Plumeeria rubra, 51% total inhibition at 0.033 mM 4-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)butanol - - 4-(acryloylamino)-N-(5-[[5-([5-[(2-carbamimidamidoethyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl]carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-2-carboxamide - a brostallicin derivative, the debrominated derivative of brostallicin is almost completely ineffective as an inhibitor of GSTP1-1 4-[(2-bromoacryloyl)amino]-N-(5-[[5-([5-[(2-carbamimidamidoethyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl]carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-2-carboxamide - i.e

Liang Z, Hu H, Li J, et al

"In general, nothing is going to make your eye turn from brown to blue," said Tooley

Environmental MLM microrobots for (E) the removal of micro/nanoplastics [117]

doi: 10.1038/s41392-023-01606-1