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Your skin makes two kinds: dark eumelanin (the one causing those patches) and lighter pheomelanin

Morselli LL, et al

The broader theme is immune regulation, not one peptide solving every inflammatory pattern

Berberine (Ber), a broad-spectrum anti-inflammatory and antioxidant agent, has also shown significant neuroprotective effects in EDC

DiNicolantonio, Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection, Ochsner J

In addition, exposure to inflammatory stimuli in vitro has been demonstrated to reduce the expression of aggrecan and SOX9 and to increase cell apoptosis in NP-MSCs, as well as promoting neurogenic differentiation which may contribute to IVD reinnervation and the development of chronic LBP