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Prior studies demonstrate that this single dose causes xerostomia in mice equivalent to fractionated dosing that recapitulates human sequalae of salivary gland radiation damage 17, 49

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Furthermore, overexpressing SLC25A40 in SLC25A39 knockout cells was sufficient to restore mitochondrial GSH levels, suggesting its redundant function in enabling mitochondrial GSH import alongside SLC25A39 (Fig

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