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Therapeutically, small trials in humans are underway: one randomized trial in mild AD is testing an oral broad-spectrum antibiotic followed by FMT to reset the microbiome [142]

Indeed, a recent study has shown that GST-pi may have a role in cell signaling

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the advances in this field have been recently reviewed elsewhere (36, 37)

Inheritable genetic mutations that release excessive TGF- from the ECM or induce over-production of the ligand will be specifically discussed in section Genetic mutations in TGF- signaling components cause bone-associated disorders