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High-fat diet-induced dysbiosis mediates MCP-1/CCR2 axis-dependent M2 macrophage polarization and promotes intestinal adenoma-adenocarcinoma sequence

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Synbiotic supplementation has also been reported to beneficially modulate inflammation, oxidative stress, and lipid metabolism, with evidence demonstrating its efficacy in lowering IS and PCS levels [182, 183]

Ethics declarations Conflict of interest This document expresses the opinion of the authors of the paper and may not be understood or quoted as being made on behalf of or reflecting the position of the European Medicines Agency or one of its committees or working parties