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In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice, a well-established animal model of PD, AD AD is the most common type of irreversible dementia and a neurodegenerative disease that often occurs in the elderly

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In addition, Nrf2 can inhibit the transcription of NF-B[104] and the encoding of proinflammatory genes, including interleukin 6 (IL-6) and IL-1[105]

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