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Notably, since SrtA already contains a Cys (C184) that is crucial for catalytic activity and may undergo undesired reactions with electrophiles, they tested several electrophiles and identified 2-chloroacetamide, which was unreactive with the native Cys184

For the future of CRPC treatment, we are excited to propose novel therapeutic targets and combination methods, as well as ideas for increasing the survival rate of CRPC patients

10.1016/j.cell.2023.11.044 163 NiuC.JiangD.GuoY.WangZ.SunQ.WangX.et al (2023)

Yes, you can still get pregnant while taking GLP-1 medications, but its a little complicated

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