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The response rates were higher for cyclosporine A and methotrexate in second-line treatment than in first-line treatment (57.3% vs 68.8% and 29.1% vs 62.7%, respectively) whereas the higher response rates for cyclophosphamide was in first-line treatment (68.2% vs 57.4%)

Be warned that your GP may not know that BSH have revised their advice within last few days and they may be using an earlier version

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

[DOI] [PubMed] [Google Scholar] 120.Khare S

Conversely, treatment with free DOX resulted in significant cell death in normal organs, particularly the heart, while the toxicity of DOX/LAAM GSH-CQDs was minimal (Supplementary Fig