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FLT3 inhibitor quizartinib induces the upregulation of inflammatory pathways in AML DTP cells and thereby confers susceptibility to anti-inflammatory glucocorticoids (GCs) (Gebru et al., 2020)

Interference with lipid metabolic pathways, including the inhibition of fatty acid -oxidation, similarly depletes DTP populations, underscoring metabolic plasticity as a fundamental vulnerability (47, 48)

There is an apparent relationship between the concentration of total glutathione and the plasma concentration of potassium and E h (Figure 2E)

USA 103 , 76077612 (2006)

In terms of administration, multiple infusion options are available, with intravenous (IV) therapy being the most prevalent

Interestingly, metazoans as a group exhibit a Met auxotrophy [135], suggesting the ability to generate Hcy from Cys was lost roughly coincident with the metazoan transition, when single-celled aquatic heterotrophic protozoans gave rise to the first primitive multicellular aquatic heterotrophic animals