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Sleep improvements typically appear within 2-4 weeks, while body composition and performance changes develop over 2-3 months, with continued optimization through 6 months

Along with recurrent metabolic vomiting, some patients with OA and UCDs present with focal neurological signs or cerebral edema

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Taken together, these lead to the accumulation of glucose causing disorders of glucose metabolism

The most parsimonious explanation for these opposing and paradoxical findings is as follows: In the fasting state, glucose provides energy for the brain, and fattyacids provide energy for nonbrain tissues

These features included molecular weight (MolWt), number of hydrogen donors and acceptors, topological polar surface area (TPSA), molecular logP (molLogP), number of rotatable bonds, heavy atom count, and ring count