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Early detection and management of CIC are crucial for minimizing the associated morbidity and mortality

Phase I clinical trial of the glutaminase inhibitor cb-839 plus capecitabine in patients with advanced solid tumors

Cleavable linkers can be divided into two broad categories: enzymatic and chemical linkers

Current strategies aimed at restoring FAO primarily involve compounds that activate the PPAR, PGC-1, and AMPK signaling pathways ( Dysregulation of the mTOR and AMPK signaling pathways has been implicated in the metabolic reprogramming of TECs during AKI

Sulfation and glucuronidation are so-called phase II detoxification reactions, the general purpose of which is to increase the water-solubility of the substrates and, thus, to facilitate their biliary and/or urinary clearance

In adipose tissue, 5-LOX interruption leads to a remarkable insulin-sensitizing effect by increasing PPAR expression, IRS1 activity, and adiponectin level that is accompanied by reduced inflammatory response