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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Drinkwater N., Gee C.L., Puri M., Criscione K.R., McLeish M.J., Grunewald G.L., Martin J.L

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A study done in mice found that only the chemical variant of cyclophosphamide that releases both acrolein and an alkylating metabolite phosphoramide mustard, but not the one that releases only acrolein, had increased the survival time of mice injected with leukaemia cells [85], supporting only weak cytostatic effects of acrolein

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For clinicians : Intervening at the systems level targeting oxidative stress, toxin burden, microbiome imbalance, and metabolic dysregulation can meaningfully slow disease progression