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ARE: antioxidant response element

10.1124/dmd.117.077818 117 WatanabeK.MatsuuraK.GaoP.HottenbacherL.TokunagaH.NishimuraK.et al (2011)

IGF-1 plays a central role in muscle development, cellular growth, and metabolic signaling

10.1086/507566 Am J Hum Genet

[1] The disease is highly age-dependent: it can manifest as early as the mid30s, but becomes more common past the age of 50, with 57 being the average age of diagnosis in the United States

J Biol Chem 277:3212432132 Deng C, Sun Z, Tong G, Yi W, Ma L, Zhao B, Cheng L, Zhang J, Cao F, Yi D (2013) -Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway